After missing the 2020 season with stage three colon cancer, Baltimore Orioles slugger Trey Mancini made an emotional and dramatic return for the 2021 season.

And he took up right where he left off, blasting home runs for the Orioles and starring in the Home Run Derby at the 2021 MLB All-Star last month.

Fittingly, Heritage Auctions has a beautiful home white Mancini jersey signed by the O’s first baseman up for bid as part of its current Bid 2 End Cancer Charity Auction.

Trey Mancini jersey up for bid in Heritage's Bid 2 End Cancer Charity Auction.

Trey Mancini jersey. 

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Heritage has partnered with Stand Up To Cancer for the unique auction, which raises money for the organization that funds and develops promising new cancer treatments.

Through a partnership with MLB and MLB teams, the auction, which runs through Oct. 25, offers game-worn jerseys and autographed memorabilia from some of the biggest stars in the game, as well as baseball items signed by famous celebrities. The event will culminate with the opportunity to bid on a chance to throw out the ceremonial first pitch at a World Series Game this fall.

The auction’s “1st Inning,” which ends Aug. 29, features such memorabilia as:

• Game-worn and signed jerseys from Manny Machado and Christian Yelich.

• Signed jerseys from Mancini, Cody Bellinger and Fernando Tatis Jr.

Signed Fernando Tatis Jr. jersey.

Fernando Tatis Jr. signed jersey. 

• A 2015 MLB All-Star Game home plate signed by Hank Aaron, Johnny Bench and Willie Mays.

Home plate from 2015 MLB All-Star Game signed by Hank Aaron, Willie Mays and Johnny Bench.

2015 home plated signed by Hank Aaron, Willie Mays and Johnny Bench. 

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• A game-used second base from Game 7 of the 2016 World Series won by the Chicago Cubs.

• A baseball signed by the 2004 National League All-Star team.

• A 2008 World Series ball signed by singer Taylor Swift.

2008 World Series ball signed by Taylor Swift.

2008 World Series ball signed by Taylor Swift. 

• A 2008 “Welcome Back Veterans” Atlanta Braves hat signed by actor Tom Hanks.

A 2008 Atlanta Braves hat signed by Tom Hanks.

Atlanta Braves hat signed by Tom Hanks. 

Stand Up To Cancer (SU2C) funds and develops the latest and most promising cancer treatments that dramatically accelerates the rate of new discoveries by connecting top scientists in the field.